Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner [Source:SGD;Acc:S000002344]

CLS8, TFP1

Chromosome IV: 126,787-130,002 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 364 orthologues, 3 paralogues and is a member of 1 Ensembl protein family.

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