Nuclear protein with a role in protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; DNA-binding protein with preference for UV-damaged DNA; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions [Source:SGD;Acc:S000002315]

Chromosome IV: 174,918-176,486 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant) and 332 orthologues.

Show transcript tableHide transcript table