Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into ER membrane under non-stress conditions; binds as dimer to transmembrane domain (TMD) cargo, shielding TMDs from aqueous solvent; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000002258]
ARR4
Chromosome IV: 282,112-283,176 reverse strand.
R64-1-1:BK006938.2
This gene has 1 transcript (splice variant) and 360 orthologues.