Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles [Source:SGD;Acc:S000002235]

CVT4, VPL18, VPL22, VPS39

Chromosome IV: 316,971-320,120 reverse strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 350 orthologues and 1 paralogue.

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