Saccharomyces cerevisiae (R64-1-1)

Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles [Source:SGD;Acc:S000002235]

Gene Synonyms

CVT4, VPL18, VPL22, VPS39


Chromosome IV: 316,971-320,120 reverse strand.


About this gene

This gene has 1 transcript (splice variant), 350 orthologues and 1 paralogue.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
Q07468 -Ensembl Canonical