Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200]

MAR1

Chromosome IV: 376,757-378,445 reverse strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 336 orthologues and 4 paralogues.

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