Saccharomyces cerevisiae (R64-1-1)
Description

Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200]

Synonyms

MAR1

Location

Chromosome IV: 376,757-378,445 reverse strand.

R64-1-1:BK006938.2

About this gene

This gene has 1 transcript (splice variant), 233 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
SIR2YDL042C_mRNA1689562aaYDL042C
 
Protein coding
P06700 NM_001180101.1
NP_010242.1

Gene-based displays