NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import [Source:SGD;Acc:S000002180]

DAR1, HOR1, OSG1, OSR5

Chromosome IV: 411,825-413,000 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 436 orthologues and 1 paralogue.

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