Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4 [Source:SGD;Acc:S000002171]

HEX3, ULS2

Chromosome IV: 429,067-430,926 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 16 orthologues and is a member of 1 Ensembl protein family.

Show transcript tableHide transcript table