Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification [Source:SGD;Acc:S000000494]

Chromosome II: 782,591-783,556 forward strand.

R64-1-1:BK006936.2

This gene has 1 transcript (splice variant), 263 orthologues and is a member of 2 Ensembl protein families.

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