Saccharomyces cerevisiae (R64-1-1)
Description

GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis [Source:SGD;Acc:S000000344]

Synonyms

GLC1, PPD1

Location

Chromosome II: 517,350-526,628 reverse strand.

R64-1-1:BK006936.2

About this gene

This gene has 1 transcript (splice variant), 219 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
IRA1YBR140C_mRNA92793092aaYBR140C
 
Protein coding
P18963 NM_001178488.3
NP_009698.3

Gene-based displays