Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000305]

Chromosome II: 443,821-444,693 reverse strand.

R64-1-1:BK006936.2

This gene has 1 transcript (splice variant) and 341 orthologues.

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