5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic [Source:SGD;Acc:S000000164]

Chromosome II: 92,414-93,394 forward strand.

R64-1-1:BK006936.2

This gene has 1 transcript (splice variant), 373 orthologues, 4 paralogues and is a member of 1 Ensembl protein family.

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