E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865]

Chromosome IV: 1,369,790-1,379,596 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 145 orthologues and 4 paralogues.

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