NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3 [Source:SGD;Acc:S000002599]

Chromosome IV: 842,337-843,449 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 224 orthologues and 4 paralogues.

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