DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]

SLD4

Chromosome XII: 343,989-345,941 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant), 345 orthologues and is a member of 1 Ensembl protein family.

Show transcript tableHide transcript table