Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins [Source:SGD;Acc:S000003527]

Chromosome VII: 1,081,584-1,082,729 reverse strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant), 9 orthologues and 13 paralogues.

Show transcript tableHide transcript table