Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to the vacuolar membrane; required for autophagy, the CVT pathway and mitophagy; potential Cdc28 substrate [Source:SGD;Acc:S000003092]
AUT12
Chromosome VII: 274,780-276,714 reverse strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant), 353 orthologues and is a member of 1 Ensembl protein family.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
MON1 | YGL124C_mRNA | 1935 | 644aa | YGL124C | Protein coding | P53129 | - | Ensembl Canonical, |