Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000003039]
RCS1
Chromosome VII: 372,012-374,084 forward strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant), 19 orthologues and 1 paralogue.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
AFT1 | YGL071W_mRNA | 2073 | 690aa | YGL071W | Protein coding | P22149 | - | Ensembl Canonical, |