Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000003039]

Chromosome VII: 372,012-374,084 forward strand.

This transcript has 1 exon, is annotated with 12 domains and features, is associated with 40 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YGL071W Show transcript tableHide transcript table