GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis [Source:SGD;Acc:S000000344]

GLC1, PPD1

Chromosome II: 517,350-526,628 reverse strand.

R64-1-1:BK006936.2

This gene has 1 transcript (splice variant), 117 orthologues, 2 paralogues and is a member of 1 Ensembl protein family.

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