2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID) [Source:SGD;Acc:S000000265]

2'-O-ribose tRNA anticodon loop methyltransferase

Chromosome II: 364,787-365,719 reverse strand.

R64-1-1:BK006936.2

This gene has 1 transcript (splice variant), 290 orthologues, 1 paralogue and is a member of 3 Ensembl protein families.

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