Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner [Source:SGD;Acc:S000006070]

Chromosome XVI: 271,310-272,194 forward strand.

This transcript has 1 exon, is annotated with 13 domains and features, is associated with 15 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YPL149W Show transcript tableHide transcript table