Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon [Source:SGD;Acc:S000005373]

Chromosome XV: 301,380-303,035 reverse strand.

This transcript has 1 exon, is annotated with 18 domains and features, is associated with 36 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YOL013C Show transcript tableHide transcript table