RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration [Source:SGD;Acc:S000004861]

Chromosome XIII: 763,351-768,039 reverse strand.

This transcript has 1 exon, is annotated with 15 domains and features, is associated with 115 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YMR247C Show transcript tableHide transcript table