Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication [Source:SGD;Acc:S000004434]

Chromosome XII: 1,019,315-1,022,251 reverse strand.

This transcript has 1 exon, is annotated with 26 domains and features and is associated with 109 variant alleles.

This transcript is a product of gene YLR442C Show transcript tableHide transcript table