Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer [Source:SGD;Acc:S000001208]

Chromosome VIII: 429,707-436,948 reverse strand.

This transcript has 1 exon, is annotated with 31 domains and features, is associated with 130 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YHR165C Show transcript tableHide transcript table