E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing [Source:SGD;Acc:S000002232]

Chromosome IV: 324,047-326,149 reverse strand.

This transcript has 1 exon, is annotated with 23 domains and features, is associated with 20 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDL074C Show transcript tableHide transcript table