Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200]

Chromosome IV: 376,757-378,445 reverse strand.

This transcript has 1 exon, is annotated with 18 domains and features and is associated with 33 variant alleles.

This transcript is a product of gene YDL042C Show transcript tableHide transcript table