Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) [Source:SGD;Acc:S000000374]

Chromosome II: 576,344-578,086 reverse strand.

This transcript has 1 exon, is annotated with 13 domains and features, is associated with 28 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YBR170C Show transcript tableHide transcript table