Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L [Source:SGD;Acc:S000004599]

Chromosome XIII: 11,483-13,174 reverse strand.

This transcript has 1 exon, is annotated with 6 domains and features, is associated with 29 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YML130C Show transcript tableHide transcript table