E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to recognize and ubiquitinate substrates of the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) [Source:SGD;Acc:S000003416]

Chromosome VII: 859,901-865,753 reverse strand.

This transcript has 1 exon, is annotated with 15 domains and features, is associated with 154 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YGR184C Show transcript tableHide transcript table