Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication [Source:SGD;Acc:S000005615]

Chromosome XV: 490,196-490,828 reverse strand.

This transcript has 1 exon, is annotated with 33 domains and features, is associated with 18 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YOR089C Show transcript tableHide transcript table