Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation [Source:SGD;Acc:S000005366]

Chromosome XV: 313,078-315,387 reverse strand.

This transcript has 1 exon, is annotated with 40 domains and features and is associated with 33 variant alleles.

This transcript is a product of gene YOL006C Show transcript tableHide transcript table