Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation [Source:SGD;Acc:S000004695]

Chromosome XIII: 445,609-448,086 reverse strand.

This transcript has 1 exon, is annotated with 35 domains and features and is associated with 57 variant alleles.

This transcript is a product of gene YMR089C Show transcript tableHide transcript table