Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication [Source:SGD;Acc:S000002503]

Chromosome IV: 637,139-639,823 forward strand.

This transcript has 1 exon, is annotated with 31 domains and features, is associated with 39 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDR096W Show transcript tableHide transcript table