Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication [Source:SGD;Acc:S000002347]

Chromosome IV: 123,865-124,998 reverse strand.

This transcript has 1 exon, is annotated with 26 domains and features and is associated with 28 variant alleles.

This transcript is a product of gene YDL188C Show transcript tableHide transcript table