Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function [Source:SGD;Acc:S000000745]

Chromosome V: 120,498-121,301 reverse strand.

This transcript has 1 exon, is annotated with 13 domains and features, is associated with 32 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YEL019C Show transcript tableHide transcript table