DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p [Source:SGD;Acc:S000002625]

Chromosome IV: 899,551-903,480 reverse strand.

This transcript has 1 exon, is annotated with 21 domains and features, is associated with 67 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDR217C Show transcript tableHide transcript table