Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane-bound ubiquitin ligase complexes that function in the ER-associated degradation (ERAD) pathway for misfolded proteins; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination and to promote diubiquitin elongation, facilitating polyubiquitin chain formation [Source:SGD;Acc:S000004877]

KIS4

Chromosome XIII: 795,805-796,416 forward strand.

R64-1-1:BK006946.2

This gene has 1 transcript (splice variant) and 15 orthologues.

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