Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112 [Source:SGD;Acc:S000005329]
Chromosome XIV: 707,788-708,195 forward strand.
R64-1-1:BK006947.3
This gene has 1 transcript (splice variant), 330 orthologues and is a member of 1 Ensembl protein family.