Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids [Source:SGD;Acc:S000004725]
Chromosome XIII: 505,333-507,207 forward strand.
R64-1-1:BK006946.2
This gene has 1 transcript (splice variant), 61 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.