WD repeat protein required for ubiquitin-mediated protein degradation; ubiquitin binding cofactor that complexes with Cdc48p; required for ribophagy; controls cellular ubiquitin concentration; promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress [Source:SGD;Acc:S000001696]

UFD3, ZZZ4

Chromosome XI: 31,960-34,107 reverse strand.

R64-1-1:BK006944.2

This gene has 1 transcript (splice variant), 352 orthologues and is a member of 1 Ensembl protein family.

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