Membrane-embedded ubiquitin-protein ligase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and a transmembrane domain containing substrate (ERAD-M), Sbh2p; C-terminal element (CTE), conserved in human ortholog MARCH10/TEB4, determines substrate selectivity [Source:SGD;Acc:S000001292]

DOA10, KIS3

Chromosome IX: 296,050-300,009 reverse strand.

R64-1-1:BK006942.2

This gene has 1 transcript (splice variant), 367 orthologues and is a member of 1 Ensembl protein family.

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