Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant [Source:SGD;Acc:S000001906]

Chromosome VI: 165,067-166,566 forward strand.

R64-1-1:BK006940.2

This gene has 1 transcript (splice variant), 177 orthologues, 15 paralogues and is a member of 1 Ensembl protein family.

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