Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF [Source:SGD;Acc:S000000918]

Chromosome V: 395,348-396,172 reverse strand.

R64-1-1:BK006939.2

This gene has 1 transcript (splice variant), 17 orthologues and is a member of 1 Ensembl protein family.

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