Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication [Source:SGD;Acc:S000000870]

NOT4, SIG1

Chromosome V: 293,050-294,813 forward strand.

R64-1-1:BK006939.2

This gene has 1 transcript (splice variant), 297 orthologues and is a member of 1 Ensembl protein family.

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