Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant [Source:SGD;Acc:S000002290]
Chromosome IV: 224,304-226,751 forward strand.
R64-1-1:BK006938.2
This gene has 1 transcript (splice variant), 411 orthologues, 2 paralogues and is a member of 1 Ensembl protein family.