Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1 [Source:SGD;Acc:S000004952]

Chromosome XIV: 618,507-619,565 reverse strand.

R64-1-1:BK006947.3

This gene has 1 transcript (splice variant), 347 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.

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