Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication [Source:SGD;Acc:S000004434]

CMT1, MAR2, STE8

Chromosome XII: 1,019,315-1,022,251 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant), 340 orthologues, 2 paralogues and is a member of 1 Ensembl protein family.

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