Description
Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene [Source:SGD;Acc:S000004133]
Location
Chromosome XII: 427,329-429,386 forward strand.
R64-1-1:BK006945.2
About this gene
This gene has 1 transcript (splice variant), 363 orthologues and is a member of 1 Ensembl protein family.
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
|---|---|---|---|---|---|---|---|---|
| DPH6 | YLR143W_mRNA | 2058 | 685aa | YLR143W | Protein coding | Q12429 | - | Ensembl Canonical, |
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