Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function [Source:SGD;Acc:S000000745]

NSE2, PSO10

Chromosome V: 120,498-121,301 reverse strand.

R64-1-1:BK006939.2

This gene has 1 transcript (splice variant), 37 orthologues and is a member of 1 Ensembl protein family.

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